Doppler ultrasound of uterine arteries in the first and third trimester of pregnancy as a predictive diagnosis of preeclampsia

Authors

  • Monserrat Cruz-Hernández Universidad Autónoma de Tamaulipas. Facultad de Medicina de Tampico “Doctor Alberto Romo Caballero”
  • José Eugenio Guerra-Cárdenas Universidad Autónoma de Tamaulipas. Facultad de Medicina de Tampico “Doctor Alberto Romo Caballero”
  • Alejandra Tavera-Tapia Universidad Autónoma de Tamaulipas. Facultad de Medicina de Tampico “Doctor Alberto Romo Caballero” https://orcid.org/0000-0002-5950-9341

Keywords:

Preeclampsia; hipertensión; embarazo

Abstract

Background

Preeclampsia and hypertensive disorders significantly impact maternal and perinatal morbidity and mortality rates, which is why markers with predictive diagnostic value are required to avoid adverse outcomes.

 

Objective

To analyze how the use of Doppler ultrasound of uterine arteries influences the prognosis of patients as a predictive study for preeclampsia or hypertensive diseases.

 

Materials and methods

Prospective design with a longitudinal approach performed at the Tampico General Hospital "Dr. Carlos Canseco.” Pregnant patients underwent Doppler evaluation of the uterine artery, giving them regular follow-ups in the first and third trimesters. Any patient with a mean Pulsatility Index (PIm) > 95 percentile was determined as pathological Doppler, consistently in all evaluations.

 

Results

ROC curve analysis was performed to assess the diagnostic accuracy of the mean uterine artery pulsatility index in the first and third trimesters for the diagnosis of preeclampsia. In the first, an area under the curve of 0.655 (Confidence Interval [CI] 95%, 0.502-0.807) was reached, and in the third, 0.76 (95% CI, 0.612-0.908), demonstrating an acceptable level of diagnostic performance.

 

Conclusions

Uterine artery PIm was found to have good diagnostic accuracy for the prediction of preeclampsia and hypertensive disorders, and its use in the third trimester has higher accuracy than first-trimester measurement.

References

1. Chappell LC, Cluver CA, Kingdom J, Tong S. Pre-eclampsia. Lancet. 2021; 398(10297):341-354. doi: 10.1016/S0140-6736(20)32335-7

2. Jung E, Romero R, Yeo L, Gomez-Lopez N, Chaemsaithong P, Jaovisidha A, et al. The etiology of preeclampsia. Am J Obstet Gynecol. 2022; 226(2S):S844-S866. doi: 10.1016/j.ajog.2021.11.1356

3. Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia-Pathophysiology and Clinical Presentations: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020; 76(14):1690-1702. doi: 10.1016/j.jacc.2020.08.014

4. Uzunov AV, Secara DC, Mehedințu C, Cîrstoiu MM. Preeclampsia and neonatal outcomes in adolescent and adult patients. J Med Life. 2022; 15(12):1488-1492. doi: 10.25122/jml-2022-0264

5. Valdés G. Preeclampsia and cardiovascular disease: an integrated approach to detect the subclinical stages of obstetrical and cardiovascular complications. Rev Chil Obstet Ginecol. 2020; 85(2): 185-200. doi: 10.4067/s0718-85602019000200132

6. Sinkey RG, Battarbee AN, Bello NA, Ives CW, Oparil S, Tita ATN. Prevention, Diagnosis, and Management of Hypertensive Disorders of Pregnancy: a Comparison of International Guidelines. Curr Hypertens Rep. 2020; 22(9):66. doi: 10.1007/s11906-020-01082-w

7. Turbeville HR, Sasser JM. Preeclampsia beyond pregnancy: long-term consequences for mother and child. Am J Physiol Renal Physiol. 2020; 318(6):F1315-F1326. doi: 10.1152/ajprenal.00071.2020

8. Wheeler SM, Myers SO, Swamy GK, Myers ER. Estimated Prevalence of Risk Factors for Preeclampsia Among Individuals Giving Birth in the US in 2019. JAMA Netw Open. 2022; 5(1):e2142343. doi: 10.1001/jamanetworkopen.2021.42343

9. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circ Res. 2019; 124(7):1094-1112. doi: 10.1161/CIRCRESAHA.118.313276

10. Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019; 15(5):275-289. doi: 10.1038/s41581-019-0119-6

11. Cairo-González VM, Jiménez-Puñales S, Machado-Benavides HL, Cardet-Niebla Y, Milián-Espinosa I, Rodríguez-Royero L. Doppler ultrasound of uterine arteries as a predictor of preeclampsia and adverse maternal and perinatal outcomes. Clin Inves Ginecol Obstet. 2021; 48 (2): 104-109. doi: 10.1016/j.gine.2020.08.002

12. Carranza-Lira S, Jaime-Barrera G, Rosales-Ortiz S, García-Espinosa M, Moreno-Álvarez O. Doppler de las arterias uterinas y braquial en mujeres sanas y con preeclampsia. Rev Med Inst Mex Seguro Soc. 2018;56(4):360-363.

13. Otero-Rosales MC, Olarte-Marín CD, Padilla-Serpa JD, Morales-Duarte PA, Quintero-Roa EM. Utilidad de la evaluación USG Doppler de las arterias uterinas entre las semanas 11 y 13+6 y su aplicación en las calculadoras de riesgo para predecir preeclampsia. Medunab. 2022; 24(3): 375–383. doi: 10.29375/01237047.3953

14. MacDonald TM, Walker SP, Hannan NJ, Tong S, Kaitu'u-Lino TJ. Clinical tools and biomarkers to predict preeclampsia. EBioMedicine. 2022;75:103780. doi: 10.1016/j.ebiom.2021.103780

15. Vidaeff AC, Saade GR, Sibai BM. Preeclampsia: The Need for a Biological Definition and Diagnosis. Am J Perinatol. 2021;38(9):976-982. doi: 10.1055/s-0039-1701023

16. Rivas M, González X, Guevara H. Valores de referencia del índice de pulsatilidad de la arteria uterina durante el embarazo. Rev Obstet Ginecol Venez. 2016; 76 (3): 152-158.

17. Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, et al. Preeclampsia and eclampsia: the conceptual evolution of a syndrome. Am J Obstet Gynecol. 2022; 226(2S): S786-S803. doi: 10.1016/j.ajog.2021.12.001

18. Stepan H, Galindo A, Hund M, Schlembach D, Sillman J, Surbek D, et al. Clinical utility of sFlt-1 and PlGF in screening, prediction, diagnosis, and monitoring of pre-eclampsia and fetal growth restriction. Ultrasound Obstet Gynecol. 2023; 61(2):168-180. doi: 10.1002/uog.26032

19. Wang X, Yip KC, He A, Tang J, Liu S, Yan R, et al. Plasma Olink Proteomics Identifies CCL20 as a Novel Predictive and Diagnostic Inflammatory Marker for Preeclampsia. J Proteome Res. 2022; 21(12):2998-3006. doi: 10.1021/acs.jproteome.2c00544

20. Kafkaslı A, Türkçüoğlu I, Turhan U. Maternal, fetal and perinatal characteristics of preeclampsia cases with and without abnormalities in uterine artery Doppler indexes. J Matern Fetal Neonatal Med. 2013; 26(9):936-940. doi: 10.3109/14767058.2013.766688

21. Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, et al. The utility of uterine artery Doppler velocimetry in prediction of preeclampsia in a low-risk population. Obstet Gynecol. 2012; 120(4):815-822. doi: 10.1097/AOG.0b013e31826af7fb

22. Razavi M, Rashidi-Fakari F, Jafari FS, et al. The role of uterine artery Doppler ultrasound in the second trimester in predicting preeclampsia. Int J Pediatrics. 2019; 7(5): 9405-9411. doi: 10.22038/ijp.2019.37066.322

23. Shwarzman P, Waintraub AY, Frieger M, Bashiri A, Mazor M, Hershkovitz R. Third trimester abnormal uterine artery Doppler findings are associated with adverse pregnancy outcomes. J Ultrasound Med. 2013; 32(12):2107–2113. doi: 10.7863/ultra.32.12.2107

24. Ahmed-Salem MA, Magdi-Ammar IM. First-Trimester Uterine Artery Pulsatility Index and Maternal Serum PAPP-A and PlGF in Prediction of Preeclampsia in Primigravida. J Obstet Gynaecol India. 2018; 68(3):192-196. doi: 10.1007/s13224-017-1012-5

25. Demers S, Bujold E, Arenas E, Castro A, Nicolaides KH. Prediction of recurrent preeclampsia using first-trimester uterine artery Doppler. Am J Perinatol. 2014; 31(2):99-104. doi: 10.1055/s-0033-1338172

26. Obican SG, Odibo L, Tuuli MG, Rodriguez A, Odibo AO. Third trimester uterine artery Doppler indices as predictors of preeclampsia and neonatal small for gestational age. J Matern Fetal Neonatal Med. 2020; 33(20):3484-3489. doi: 10.1080/14767058.2019.1575804

Published

2025-06-25

How to Cite

Cruz-Hernández, M., Guerra-Cárdenas, J. E., & Tavera-Tapia, A. (2025). Doppler ultrasound of uterine arteries in the first and third trimester of pregnancy as a predictive diagnosis of preeclampsia. ARCHIVOS DE MEDICINA, SALUD Y EDUCACIÓN MÉDICA, 4(1), 6–14. Retrieved from https://archivosdemedicina.uat.edu.mx/index.php/nuevo/article/view/76

Issue

Section

Artículos
Received 2024-09-24
Accepted 2025-05-15
Published 2025-06-25